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Article Publish Status: FREE
Abstract Title:

Polysaccharide from black currant (L.) stimulates dendritic cells through TLR4 signaling.

Abstract Source:

Biosci Microbiota Food Health. 2017 ;36(4):141-145. Epub 2017 Jul 4. PMID: 29038769

Abstract Author(s):

Hiroshi Ashigai, Yuta Komano, Guanying Wang, Yasuji Kawachi, Kazuko Sunaga, Reiko Yamamoto, Ryoji Takata, Mika Miyake, Takaaki Yanai

Article Affiliation:

Hiroshi Ashigai

Abstract:

Black currant () has various beneficial properties for human health. In particular, polysaccharide from black currant was found to be an immunostimulating food ingredient and was reported to have antitumor activity in a mouse model. We named it cassis polysaccharide (CAPS). In a previous study, CAPS administration caused tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) productionand, but the immunological mechanism of CAPS was not demonstrated. In this study, we revealed the CAPS immunostimulating mechanism. First, we found that CAPS activated dendritic cells (DCs). Second, we investigated whether it depends on Toll-like receptor 4 (TLR4) and myeloid differentiation primary response (Myd). We concluded that CAPS stimulates DCs through Myd88 depending TLR4 signaling and activates Th1-type cytokine release.

Study Type : In Vitro Study

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