Abstract Title:

Anti-inflammatory and angiogenic activity of polysaccharide extract obtained from Tibetan kefir.

Abstract Source:

Microvasc Res. 2016 Nov ;108:29-33. Epub 2016 Jul 11. PMID: 27418582

Abstract Author(s):

Maria Rosa Machado Prado, Christian Boller, Rosiane Guetter Mello Zibetti, Daiany de Souza, Luciana Lopes Pedroso, Carlos Ricardo Soccol

Article Affiliation:

Maria Rosa Machado Prado


The search for new bioactive molecules is a driving force for research pharmaceutical industries, especially those molecules obtained from fermentation. The molecules possessing angiogenic and anti-inflammatory attributes have attracted attention and are the focus of this study. Angiogenic activity from kefir polysaccharide extract, via chorioallantoic membrane assay, exhibited a pro-angiogenic effect compared with vascular endothelial factor (pro-angiogenic) and hydrocortisone (anti-angiogenic) activity as standards with an EC50 of 192ng/mL. In terms of anti-inflammatory activity determined via hyaluronidase enzyme assay, kefir polysaccharide extract inhibited the enzyme with a minimal activity of 2.08mg/mL and a maximum activity of 2.57mg/mL. For pharmaceutical purposes, kefir polysaccharide extract is considered to be safe because it does not inhibit VERO cells in cytotoxicity assays.

Study Type : In Vitro Study

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