Polysaccharide from the Seeds ofL. Protect Against Lipopolysaccharide-Induced Liver Injury.
J Med Food. 2019 Sep 27. Epub 2019 Sep 27. PMID: 31560611
Previous studies have proven that polysaccharide obtained from the seeds ofL. (PLCP) could induce maturation of murine dendritic cells, promote defecation, and possess antioxidant activity. However, the effect of PLCP on lipopolysaccharide (LPS)-induced liver injury in mice has been rarely reported. In this study, we investigated the anti-inflammatory effect of PLCP on LPS-induced liver injury. Mice were pretreated orally with different dose of PLCP for 3 weeks. On day 22, they were injected intraperitoneally with LPS and sacrificed 12 h later. The results showed that PLCP inhibited the excessive production of tumor necrosis factor-, interleukin (IL)-6, IL-10, IL-2, and IL-1in mouse serum and liver. PLCP also improved glutathione peroxidase and total antioxidant capacity activities in mouse liver. In addition, PLCP inhibited nitric oxide, inducible nitric oxide synthase, and cyclooxygenase-2 expression, and increased metallothionein production in mouse liver. Consequently, PLCP may possess protective effects on inflammatory associated liver injury.