Abstract Title:

Polysaccharides from Cordyceps miltaris cultured at different pH: Sugar composition and antioxidant activity.

Abstract Source:

Int J Biol Macromol. 2020 Jun 20 ;162:349-358. Epub 2020 Jun 20. PMID: 32574745

Abstract Author(s):

Yuntao Liu, Yiwen Li, Huilan Zhang, Cheng Li, Zhiqing Zhang, Aiping Liu, Hong Chen, Bin Hu, Qingying Luo, Bokun Lin, Wenjuan Wu

Article Affiliation:

Yuntao Liu


In the study, theβ-glucan content, the primary structure and the antioxidant capacity of polysaccharides in Cordyceps militaris cultivated with different initial growth pH were evaluated. Meanwhile, the mechanism of β-glucan biosynthesis was investigated by RNA-Seq. Based on the results, C. militaris growing at aninitial growth pH of 5-7 (CMsA) was distinguished from C. militaris growing at an initial growth pH of 8-9 (CMsB) and their unigenes showed the comparable expression. The mean of β-glucan content of CMsB group was 32.7% (w/w), 10% higher than that of CMsA. The results of RNA-seq showed 1088 differentially expressed genes between CMsA and CMsB groups. Furthermore, oxidative phosphorylation-related Gene ontology terms were up-regulated in CMsB groups. In addition, the results of structural analysis (FTIR spectrum, monosaccharide composition, periodate oxidation) and bioactivity evaluation speculated that C. militaris polysaccharides possessed higher β-(1 → 6)-glucan content and antioxidant activities in CMsB groups.

Study Type : In Vitro Study

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