Polysaccharides obtained fromofattenuated doxorubicin-induced cytotoxic effects in chemotherapy.
Afr Health Sci. 2019 Jun ;19(2):2156-2163. PMID: 31656500
Objectives: militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured forproduction. To evaluate the potential of polysaccharides obtained fromof(PS-MCM) for attenuation of side-effects of chemotherapy.
Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells.
Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells.
Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.