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Article Publish Status: FREE
Abstract Title:

Polysaccharides obtained fromofattenuated doxorubicin-induced cytotoxic effects in chemotherapy.

Abstract Source:

Afr Health Sci. 2019 Jun ;19(2):2156-2163. PMID: 31656500

Abstract Author(s):

Ruo-Kai Lin, Chen-Yen Choong, Wei-Hsuan Hsu, Chen-Jei Tai, Cheng-Jeng Tai

Article Affiliation:

Ruo-Kai Lin

Abstract:

Objectives: militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured forproduction. To evaluate the potential of polysaccharides obtained fromof(PS-MCM) for attenuation of side-effects of chemotherapy.

Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells.

Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells.

Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.

Study Type : In Vitro Study

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Sayer Ji
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