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Abstract Title:

Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions.

Abstract Source:

Ann Allergy Asthma Immunol. 2005 Dec ;95(6):593-9. PMID: 16400901

Abstract Author(s):

Esther A Coors, Heidi Seybold, Hans F Merk, Vera Mahler

Article Affiliation:

Esther A Coors

Abstract:

BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has declined during the past decades, it is of current relevance as a"hidden"inductor of anaphylactoid reactions.

OBJECTIVE: To identify polysorbate 80 (generally believed to be an inert vehicle) as an inductor of a severe anaphylactoid reaction.

METHODS: Skin prick testing, enzyme-linked immunosorbent assay, IgE immunoblotting, and flow cytometric detection of basophil activation were performed in controls and in a patient with a medical history of anaphylactic shock due to intravenous administration of a multivitamin product during pregnancy.

RESULTS: Polysorbate 80 was identified as the causative agent for the anaphylactoid reaction of nonimmunologic origin in the patient. Polysorbate specific IgE antibodies were not identified in enzyme-linked immunosorbent assay and immunoblot examinations, confirming the nonimmunologic nature of the anaphylactoid reaction.

CONCLUSIONS: Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions.

Study Type : Review
Additional Links
Additional Keywords : Vaccine Adjuvant : CK(17) : AC(6)
Problem Substances : Polysorbate 80 : CK(1) : AC(1)

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