Antimicrobial Activity of Pomegranate and Green Tea Extract onPropionibacterium Acnes, Propionibacterium Granulosum, Staphylococcus AureusandStaphylococcus Epidermidis.
J Drugs Dermatol. 2015 Jun 1 ;14(6):574-8. PMID: 26091382
We used pomegranate extract (POMx), pomegranate juice (POM juice) and green tea extract (GT) to establish in vitro activities against bacteria implicated in the pathogenesis of acne. Minimum inhibitory concentrations (MIC) of 94Propionibacterium acnes, Propionibacterium granulosum, Staphylococcus aureus,andStaphylococcus epidermidisstrains were determined by Clinical and Laboratory Standards Institute-approved agar dilution technique. Total phenolics content of the phytochemicals was determined using the Folin-Ciocalteu method and the polyphenol composition by HPLC. Bacteria were identified by 16S rRNA sequence analysis. GT MIC of 400μg/ml or less was obtained for 98% of the strains tested. 64% ofP. acnesstrains had POMx MICs at 50μg/ml whereas 36% had MIC>400μg/ml. POMx, POM juice, and GT showed inhibitory activity against all theP. granulosumstrains at≤100μg/ml. POMx and GT inhibited all theS. aureusstrains at 400μg/ml or below, and POM juice had an MIC of 200μg/ml against 17S. aureusstrains. POMx inhibitedS. epidermidisstrains at 25μg/ml, whereas POM juice MICs were≥200μg/ml. The antibacterial properties of POMx and GT on the most common bacteria associated with the development and progression of acne suggest that these extracts may offer a better preventative/therapeutic regimen with fewer side effects than those currently available.
J Drugs Dermatol. 2015;14(6):574-578.