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Abstract Title:

The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis.

Abstract Source:

J Sci Food Agric. 2016 Jan 25. Epub 2016 Jan 25. PMID: 26804926

Abstract Author(s):

Nasrin Ghoochani, Majid Karandish, Karim Mowla, Mohammad Hossein Haghighizadeh, Mohammad Taha Jalali

Article Affiliation:

Nasrin Ghoochani

Abstract:

BACKGROUND: Osteoarthritis (OA) is one of the commonest forms of musculoskeletal disorders that leads to joint degeneration and has a major impact on patients' quality of life. Experimental and in vitro studies have suggested the protective roles of pomegranate juice (PJ) as a rich antioxidant source for mitigating cartilage inflammation. In this interventional study, 38 patients with knee OA were randomly divided into two groups: PJ or control for 6 weeks to evaluate the effect of this intervention on clinical signs, inflammation and antioxidant status.

RESULTS: Significant decreases in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) total score (P= 0.01), stiffness score (p=0.00) and physical function score (p=0.01) were observed in PJ group after the intervention. The means of serum levels of matrix metalloproteinase (MMP) -13 was significantly decreased (p=0.02) and glutathione peroxidase was increased in the intervention group compared with the control group after the study period (p=0.02).

CONCLUSIONS: According to the findings of this clinical trial, PJ consumption can improve physical function and stiffness, decrease breakdown cartilage enzymes and increase antioxidant status in patients with knee OA.

Study Type : Human Study

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Sayer Ji
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