Abstract Title:

Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells.

Abstract Source:

Anticancer Res. 2011 Sep ;31(9):2699-704. PMID: 21868510

Abstract Author(s):

Vidhya Nair, Zhaoli Dai, Maruf Khan, Henry P Ciolino

Article Affiliation:

Office of Cancer Centers, National Cancer Institute, Building 6116, Room 7002, Rockville, MD 20892, U.S.A. [email protected].

Abstract:

BACKGROUND: Pomegranate extract (PE) is a standardized whole-fruit extract of pomegranate, a fruit with known anticancer properties.

MATERIALS AND METHODS: PANC-1 and AsPC-1 human pancreatic cancer cells were used as in vitro models to test the effects of PE.

RESULTS: PE treatment induced cell cycle arrest and inhibited cell proliferation in PANC-1 cells. PE treatment increased the proportion of cells lacking CD44 and CD24 expression, which are associated with increased tumor-initiating ability, demonstrating that PE altered cell phenotype. PE was more effective in inhibiting the proliferation of PANC-1 cells than the clinically used dose of paclitaxel. Similar results were obtained in the AsPC-1 cell line. Individual pomegranate phytochemicals were only modestly effective in inhibiting cell proliferation, suggesting that unidentified phytochemicals are responsible for the inhibitory effect of PE.

CONCLUSION: These data suggest that PE is a promising candidate for further preclinical testing for treatment of human pancreatic cancer.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.