Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high fat and high sucrose diet-induced-obesity mice model.
Arch Physiol Biochem. 2016 Jan 28:1-40. Epub 2016 Jan 28. PMID: 26822470
OBJECTIVE: The potentially beneficial effects of Pomegranate peel (PPE), flower (PFE) and seed oil (PSO) extracts, in comparison with rosiglitazone, on adiposity, lipid profile, glucose homeostasis, as well as on the underlying inflammatory mechanisms, were examined in high fat and high sucrose (HF-HS) diet-induced obese (DIO) mice.
MEASUREMENTS: Body weight, body fat, energy expenditure, food and liquid intake, blood glucose, and plasma levels of insulin, lipids and cytokines were measured.
RESULTS: After two weeks, PSO (2 ml/kg/day) and rosiglitazone (3 mg/kg/day) had not improved glucose intolerance. After 4 weeks, both treatments significantly reduced fasting blood glucose and an insulin tolerance test showed that they also improved insulin sensitivity. Treatment with PPE, PFE and PSO, reduced the plasma levels of the pro-inflammatory cytokines IL-6 and TNF-α, and PFE increased the level of the anti-inflammatory cytokine IL-10.
CONCLUSION: PPE, PFE and PSO have anti-inflammatory properties. PSO also improved insulin sensitivity.