Pomegranate seed compounds have estrogen receptor enzyme modulating activity. - GreenMedInfo Summary

Abstract Title:

Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity.

Abstract Source:

Atherosclerosis. 2007 Aug;193(2):277-82. Epub 2006 Sep 29. PMID: 20136514

Abstract Author(s):

Hoang Ngoc Ai Tran, Soo-Young Bae, Bang-Ho Song, Bang-Hyo Lee, Young-Seok Bae, Young-Ho Kim, Ephraim Philip Lansky, Robert A Newman

Article Affiliation:

Department of Experimental Therapeutics, Kyungpook National University, Taegu, Republic of Korea.

Abstract:

Pomegranate (Punica granatum) seed linolenic acid isomers were evaluated as selective estrogen receptor modulators (SERMs) in vitro. Punicic acid (PA) inhibited (IC(50)) estrogen receptor (ER) alpha at 7.2 microM, ERbeta at 8.8 microM; alpha-eleostearic acid (AEA) inhibited ERalpha/ERbeta at 6.5/7.8 microM. PA (not AEA) agonized ERalpha/ERbeta (EC(50)) at 1.8/2 microM, antagonizing at 101/80 microM. AEA antagonized ERalpha/ERbeta at 150/140 microM. PA and AEA induced ERalpha and ERbeta mRNA expression in MCF-7, but not in MDA-MB-231. Overall, the results show PA and AEA are SERMs.

Article Published Date : Aug 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid) : CK(73) : AC(29), Pomegranate : CK(1721) : AC(554)
Diseases : Breast Cancer : CK(6327) : AC(2840)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(6958), Estrogen Receptor Modulators : CK(58) : AC(39), Selective estrogen enzyme modulator (SEEM) : CK(9) : AC(7), Selective Estrogen Receptor Modulators : CK(8) : AC(5)
Additional Keywords : Estrogen Receptor Beta : CK(34) : AC(18)

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Key Research Topics

Substance

CLA (Conjugated Linoleic Acid)
Pomegranate

Disease

Breast Cancer

Pharmacological Actions

Estrogen Receptor Modulators
Selective Estrogen Receptor Modulators
Antiproliferative
Selective estrogen enzyme modulator (SEEM)

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