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Article Publish Status: FREE
Abstract Title:

Effects of portulacerebroside a on apoptosis of human leukemia HL60 cells and p38/JNK signaling pathway.

Abstract Source:

Int J Clin Exp Pathol. 2015 ;8(11):13968-77. Epub 2015 Nov 1. PMID: 26823708

Abstract Author(s):

Qidong Ye, Na Zhang, Kai Chen, Jiashi Zhu, Hui Jiang

Article Affiliation:

Qidong Ye

Abstract:

Acute myeloid leukemia is known as one of the most malignant diseases. We aimed at exploring the effect of portulacerebroside A (PCA) on the apoptosis in human leukemia HL60 cells and clarify the possible mechanisms involved in. By MTT analysis, we found that PCA (1-100μM) inhibited the cell viability in a time- and dose-dependent manner, and cell cycle was arrested at G0/G1 period. PCA treatment from 5 to 50 μM dose-dependently induced apoptosis from 12.7 ± 1.56% to 52.7 ± 6.214% of HL60 cells. Mitochondrial membrane potential (MMP) was decreased and reactiveoxygen species (ROS) accumulated obviously. mRNA expressions and protein levels of Bax/Bcl-2, caspase-3 and caspase-9 were elevated significantly. ERK1/2, JNK1/2 and p38 MAPK pathway were blocked detected by western blot analysis. In conclusion, PCA can act as a new agent for leucocythemia treatment.

Study Type : In Vitro Study

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Sayer Ji
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