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Article Publish Status: FREE
Abstract Title:

Possible therapeutic effects ofand its thymoquinone on COVID-19.

Abstract Source:

Pharm Biol. 2021 Dec ;59(1):696-703. PMID: 34110959

Abstract Author(s):

Mohammad Reza Khazdair, Shoukouh Ghafari, Mahmood Sadeghi

Article Affiliation:

Mohammad Reza Khazdair

Abstract:

CONTEXT: COVID-19 is a novel coronavirus that causes a severe infection in the respiratory system.L. (Ranunculaceae) is an annual flowering plant used traditionally as a natural food supplement and multipurpose medicinal agent.

OBJECTIVE: The possible beneficial effects of, and its constituent, thymoquinone (TQ) on COVID-19 were reviewed.

METHODS: The key words including, COVID-19,, thymoquinone, antiviral effects, anti-inflammatory and immunomodulatory effects in different databases such as Web of Science (ISI), PubMed, Scopus, and Google Scholar were searched from 1990 up to February 2021.

RESULTS: The current literature review showed thatand TQ reduced the level of pro-inflammatory mediators including, IL-2, IL-4, IL-6, and IL-12, while enhancing IFN-γ.and TQ increased the serum levels of IgG1 and IgG2a, and improved pulmonary function tests in restrictive respiratory disorders.

DISCUSSION AND CONCLUSIONS: These preliminary data of molecular docking, animal, and clinical studies proposeand TQ might have beneficial effects on the treatment or control of COVID-19 due to antiviral, anti-inflammatory and immunomodulatory properties as well as bronchodilatory effects. The efficacy ofand TQ on infected patients with COVID-19 in randomize clinical trials will be suggested.

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