Article Publish Status: FREE
Abstract Title:

Potential protective roles of phytochemicals on glutamate-induced neurotoxicity: A review.

Abstract Source:

Iran J Basic Med Sci. 2020 Sep ;23(9):1113-1123. PMID: 32963732

Abstract Author(s):

Amir R Afshari, Sahar Fanoudi, Arezoo Rajabian, Hamid R Sadeghnia, Hamid Mollazadeh, Azar Hosseini

Article Affiliation:

Amir R Afshari


Glutamate, as an essential neurotransmitter, has been thought to have different roles in the central nervous system (CNS), including nerve regeneration, synaptogenesis, and neurogenesis. Excessive glutamate causes an up-regulation of the multiple signaling pathways, including phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Akt/mammalian target of rapamycin (mTOR) protein, mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)1/2, and autophagy that are involved in neurodegenerative diseases pathophysiology. There are numerous findings on curcumin, astaxanthin, thymoquinone, and berberine, as natural products, which have outstanding effects in cell signaling far beyond their anti-oxidant activity, considering as a potential therapeutic target for glutamate excitotoxicity. Herein, we address the role of glutamate as a potential target in neurodegenerative diseases and discuss the protective effects of certain phytochemicals on glutamate-induced neurotoxicity.

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