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Abstract Title:

Potential therapeutic and pharmacological effects of Wogonin: an updated review.

Abstract Source:

Mol Biol Rep. 2020 Dec ;47(12):9779-9789. Epub 2020 Nov 9. PMID: 33165817

Abstract Author(s):

Do Luong Huynh, Tran Hoang Ngau, Nguyen Hoai Nguyen, Gia-Buu Tran, Cuong Thach Nguyen

Article Affiliation:

Do Luong Huynh

Abstract:

Flavonoids are members of polyphenolic compounds, which are naturally presented in fruits, vegetables, and some medicinal plants. Traditionally, the root of Scutellaria baicalensis is widely used as Chinese herbal medicine and contains several major bioactive compounds such as Wogonin, Scutellarein, Baicalein, and Baicalin. Experimental and clinical evidence has been proving that Wogonin exhibits diverse biological activities such as anti-cancer, anti-inflammation, and treatment of bacterial and viral infections. In this review, we summarize and emphasize the benefits of Wogonin as a therapeutic adjuvant for anti-viral infection, anti-inflammation, neuroprotection as well as anxiolytic and anticonvulsant. Moreover, the molecular mechanism(s) how Wogonin mediates the cellular signal pathways and immune responses are also discussed and highlighted valuable properties of Wogonin in multiple therapies.

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