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Abstract Title:

The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine.

Abstract Source:

IUBMB Life. 2020 Oct 27. Epub 2020 Oct 27. PMID: 33107698

Abstract Author(s):

Zahra Ghaneifar, Zahra Yousefi, Fatemeh Tajik, Banafsheh Nikfar, Fatemeh Ghalibafan, Elham Abdollahi, Amir Abbas Momtazi-Borojeni

Article Affiliation:

Zahra Ghaneifar

Abstract:

Pregnancy complications including preeclampsia, preterm birth, intrauterine growth restriction, and gestational diabetes are the main adverse reproductive outcomes. Excessive inflammation and oxidative stress play crucial roles in the pathogenesis of pregnancy disorders. Curcumin, the main polyphenolic compound derived from Curcuma longa, is mainly known by its anti-inflammatory and antioxidant properties. There are in vitro and in vivo reports revealing the preventive and ameliorating effects of curcumin against pregnancy complications. Here, we aimed to seek mechanisms underlying the modulatory effects of curcumin on dysregulated inflammatory and oxidative responses in various pregnancy complications.

Study Type : Review

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