Pravastatin-induced colitis has been reported. - GreenMedInfo Summary
Eur J Gastroenterol Hepatol. 2008 Aug ;20(8):810-2. PMID: 18617789
Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
We report an unusual case of pravastatin-induced colitis in an 80-year old lady. Onset of symptoms was noted within 48 h of starting the medication. Colonoscopy revealed diffuse ulceration throughout the colon with relative sparing of the rectum, with the biopsies showing ulceration and inflammation. The patient received a short course of steroid therapy and 5 months after stopping pravastatin, there was complete macroscopic and microscopic resolution of the colonic lesions. Drug interaction of pravastatin with amitryptiline could have resulted in this uncommon complication.