Article Publish Status: FREE
Abstract Title:

Comparing the Effect of Preoperative Administration of Melatonin andon Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery.

Abstract Source:

Anesth Pain Med. 2017 Feb ;7(1):e41238. Epub 2016 Oct 2. PMID: 28920038

Abstract Author(s):

Faranak Rokhtabnak, Mohammad Reza Ghodraty, Alireza Kholdebarin, Ali Khatibi, Seyedeh Somayeh Seyed Alizadeh, Zahra Sadat Koleini, Mohammad Mahdi Zamani, Alireza Pournajafian

Article Affiliation:

Faranak Rokhtabnak


BACKGROUND: Anxiety is a preoperative complication, which most patients encounter. The use of a premedication to reduce preoperative anxiety with minimal cognitive impairment is crucial.

OBJECTIVES: This study was conducted to compare the sedative effect of preoperative melatonin andin patients undergoing elective surgery regarding their potential for postoperative cognitive disorders.

METHODS: In this clinical trial, 52 patients American society of anesthesiologists grade (ASA) I and II of both genders were selected to receive either(1000 mg nature made) (n = 26) or melatonin (6 mg) (n = 26) as premedication one hour before surgery. Post-operative pain was evaluated using the visual analogue scale (VAS). Patient's anxiety and cognitive dysfunction was evaluated with the Ramsey score and the digital symbol substitution test (DSST), respectively. All tests were carried out and evaluated at arrival in the operating room, before induction and before discharge from the post anesthesia care unit (PACU).

RESULTS: There were no statistically differences between groups in VAS (P>0.05). However, the mean score of pain was higher in the melatonin group compared to thegroup when discharged from the PACU (27.63 vs. 25.37). The anxiety scores were statistically significant in both drugs (P = 0.001), however higher sedation scores was caused by premedication with melatonin (P = 0.003 vs. 0.008). Regarding the DSST, there was a significant difference between the two groups one hour before the surgery (P = 0.04) and at the time of discharge from the PACU (P = 0.007). When evaluating each group, thegroup revealed a significant difference (P = 0.003).

CONCLUSIONS: Our findings show that premedication withreduces anxiety as well as Melatonin. However, Melatonin causes less cognitive impairment compared to.

Study Type : Human Study

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Sayer Ji
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