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Abstract Title:

Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats.

Abstract Source:

Int J Biol Macromol. 2020 May 22. Epub 2020 May 22. PMID: 32450327

Abstract Author(s):

Wanchao Chen, Di Wu, Yueling Jin, Qiaozhen Li, Yanfang Liu, Xuxin Qiao, Jingsong Zhang, Guochao Dong, Zhengpeng Li, Tingting Li, Yan Yang

Article Affiliation:

Wanchao Chen

Abstract:

Theβ-glucan H6PC20 (Mw: 2390 kDa) and α-heteropolysaccharide HPB-3 (Mw: 15 kDa) were purified from the fruiting body of Hericium erinaceus according to the previous methods. Their gastroprotective activities and corresponding structure-activity relationship were studied in the ethanol-induced gastric ulcer model of rats. After intragastric administrated with H6PC20 and HPB-3 for 14 days, macroscopic and histological evaluation of gastric mucosa was improved significantly. The defense and repair factors (EGF, bFGF and PGE) were increased, meanwhile, the inflammatory cytokines (IL-1β and TNF-α) and MDA were reduced. These results indicated that H6PC20 and HPB-3 presented gastroprotective activities with the mechanism of activating repair and defense system, decreasing the inflammatory response and alleviating the oxidative injury. Furthermore, the structure-activity relationship showed that the macromolecular β-glucan was better for repair and defense system, while the low weight molecular α-heteropolysaccharide focused on the anti-inflammatory effect. The polysaccharides purified from H. erinaceus can be developed as a potential gastroprotective ingredient for applications in pharmaceutical field.

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