Article Publish Status: FREE
Abstract Title:

Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced byInfection in Human Gastric Epithelial Cells.

Abstract Source:

Antioxidants (Basel). 2021 Jun 11 ;10(6). Epub 2021 Jun 11. PMID: 34208004

Abstract Author(s):

Jose Manuel Silvan, Alba Gutierrez-Docio, Esperanza Guerrero-Hurtado, Lucia Domingo-Serrano, Ana Blanco-Suarez, Marin Prodanov, Teresa Alarcon-Cavero, Adolfo J Martinez-Rodriguez

Article Affiliation:

Jose Manuel Silvan


() is a pathogenic bacteria identified as a potential risk factor for gastritis, gastric ulcers and gastric cancer. During the stomach colonization,triggers a strong inflammatory response and subsequent oxidative stress, which are associated with tissue damage. For this reason, it is of particular interest to develop alternative natural tools that enable modulation of the associated damaging immune response. With this purpose, we obtained grape seed extract (GSE) from sweet (not fermented) food grade seeds. The aim of our study was to investigate the effect of GSE and its two enriched procyanidins fractions (OPC and PPC) on the inflammatory process and oxidative stress produced by differentstrains in human gastric epithelial cells (AGS). Anti-inflammatory activity was evaluated by measuring the level of interleukin-8 (IL-8) secretion. IL-8 production was significantly reduced in-infected human gastric epithelial cells pre-treated with GSE or its enriched fractions when compared with non-pre-treated infected cells (from 21.6% to 87.8%). Pre-treatment with GSE or its fractions significantly decreased intracellular reactive oxygen species (ROS) production in AGS cells after infection, depending on thestrain. Our results also showed that GSE and its fractions demonstrate antibacterial activity against all strains ofused in the study. This work demonstrates the effectiveness of GSE enriched in procyanidins against the main events associated withinfection.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.