Article Publish Status: FREE
Abstract Title:

Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice.

Abstract Source:

Nutrients. 2021 Apr 24 ;13(5). Epub 2021 Apr 24. PMID: 33923174

Abstract Author(s):

Audrey M Neyrinck, Cándido Robles Sánchez, Julie Rodriguez, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne

Article Affiliation:

Audrey M Neyrinck


Berberine and curcumin, used as food additives or food supplements, possess interesting anti-inflammatory and antioxidant properties. We tested the potential protective effect of both phytochemicals in genetically obese mice and we determined whether these effects can be related to the modulation of gut functions and microbiota.mice were fed a standard diet supplemented with or without 0.1% berberine and/or 0.3% curcumin for 4 weeks. By using targeted qPCR, we found that cecal content ofspp. andspp. increased mainly upon berberine supplementation. Genes involved in innate immunity (), mucus production () and satietogenic peptide production (andwere upregulated in the colon of mice treated with both phytochemicals. Berberine supplementation alone reduced food intake, body weight gain, hypertriglyceridemia and hepatic inflammatory and oxidative stress markers, thus lessening hepatic injury. The increase inspp. andspp. was correlated with the improvement of gut barrier function and with the improvement of hepatic inflammatory and oxidative stresses in obese mice. These data support the fact that non-carbohydrate phytochemicals may modulate the gut microbiota in obesity and related gut and hepatic alterations.

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