Abstract Title:

Bone demineralization in the lumbar spine of dogs submitted to prednisone therapy.

Abstract Source:

J Vet Pharmacol Ther. 2010 Dec;33(6):583-6. PMID: 21062311

Abstract Author(s):

L A V S Costa, B F Lopes, A B Lanis, D C De Oliveira, J G Giannotti, F S Costa

Article Affiliation:

Departamento de Medicina Veterinária, Centro de Ciências Agrárias da Universidade Federal do Espírito Santo (CCA-UFES), Alto Universitário s/no Alegre-ES, Brazil.

Abstract:

Costa, L. A. V. S., Lopes, B. F., Lanis, A. B., de Oliveira, D. C., Giannotti, J. G., Costa, F. S. Bone demineralization in the lumbar spine of dogs submitted to prednisone therapy. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01174.x. Glucocorticoids are drugs widely used in veterinary medicine; however, besides their clinical benefits, their use can trigger undesirable effects. A clinical trial was performed on eight healthy dogs with the intent of evaluating possible alterations in the bone mineral density after therapy with prednisone using a helical computed tomography. All animals received prednisone orally at a dose of 2 mg/kg of weight for 30 days. The bone mineral density was determined by obtaining the vertebral body radiodensity of the second lumbar vertebra values immediately before and after the administration of the medication. The experimental protocol allowed for the characterization of a significant (P < 0.01) reduction of the vertebral body radiodensity of the second lumbar vertebra. At the end of the experiment, it was characterized by a loss of bone mass of approximately 14%. None of the animals presented pathologic fracture at the end of the administration of the medication. This study verified that the alterations in the bone metabolism of the dogs submitted to the therapy with prednisone in a dosage of 2 mg/kg occur rapidly, which recommends a monitoring of the patients for the prevention of pathologic fractures.

Study Type : Animal Study
Additional Links
Problem Substances : Prednisone : CK(170) : AC(19)

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