Abstract Title:

Mood and Microbes: Gut to Brain Communication in Depression.

Abstract Source:

Gastroenterol Clin North Am. 2019 09 ;48(3):389-405. Epub 2019 Jun 12. PMID: 31383278

Abstract Author(s):

John R Kelly, Veronica O' Keane, John F Cryan, Gerard Clarke, Timothy G Dinan

Article Affiliation:

John R Kelly


The gut microbiota, acting via the gut-brain axis, modulates key neurobiological systems that are dysregulated in stress-related disorders. Preclinical studies show that the gut microbiota exerts an influence over neuroimmune and neuroendocrine signaling pathways, in addition to epigenetic modification, neurogenesis, and neurotransmission. In humans, preliminary evidence suggests that the gut microbiota profile is altered in depression. The full impact of microbiota-based treatments, at different neurodevelopmental time points, has yet to be fully explored. The integration of the gut microbiota, as a mediator, in the complex trajectory of depression, may enhance the possibility of personalized precision psychiatry.

Study Type : Review

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