Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Brazil nut consumption modulates Nrf2 expression in hemodialysis patients: A Pilot Study.

Abstract Source:

Mol Nutr Food Res. 2016 Mar 15. Epub 2016 Mar 15. PMID: 26992136

Abstract Author(s):

Ludmila F M F Cardozo, Milena B Stockler-Pinto, Denise Mafra

Article Affiliation:

Ludmila F M F Cardozo

Abstract:

SCOPE: Previous studies showed that the supplementation with Brazil nut is effective in improving Se status, reduce oxidative stress and inflammation in hemodialysis (HD) patients. As the nutritional compounds may promote the reduction of inflammation by activation of nuclear factor E2-related factor 2 (Nrf2), the aim of this pilot study was to evaluate the effects of Brazil nut supplementation on Nrf2 activation in HD patients.

METHODS AND RESULTS: Thirteen HD patients received one Brazil nut supplementation per day for 3 months and were compared to twelve HD patients without supplementation. Peripheral blood mononuclear cells (PBMC) were isolated and processed for expression of nuclear factor kappa B (NF-κB), Nrf2 and quinoneoxidoreductase 1 (NQO1) by quantitative real-time polymerase chain reaction. Plasma malondialdehyde (MDA), C-reactive protein (CRP) and IL-6 levels were measured before and after supplementation. The Nrf2 expression increased and NF-κB expression reducedpost supplementation. In addition, the cytokines and MDA levels decreased significantly. No significant alterations were found in the control group.

CONCLUSION: This preliminary result indicates the effectiveness of Brazil nut supplementation on human Nrf2 activation in HD patients and could be a possible explanation for the beneficial effects of this nut as a bioactive compound. This article is protected by copyright. All rights reserved.

Study Type : Human Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.