Prenatal antibiotic treatment does not decrease group B streptococcus colonization at delivery.
Int J Gynaecol Obstet. 2008 May;101(2):125-8. Epub 2007 Dec 20. PMID: 18082163
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL, USA. firstname.lastname@example.org
OBJECTIVE: To evaluate whether an outpatient antibiotic regimen decreased group B streptococcal (GBS) colonization to preclude the use of intrapartum antibiotics.
METHODS: A double-blind randomized controlled trial evaluating prenatal oral amoxicillin versus placebo with the primary outcome of GBS colonization at the time of labor.
RESULTS: Of those patients receiving both amoxicillin and a repeat culture at the time of labor, 6 of the 14 (43%) tested positive for GBS colonization. Given persistent GBS colonization of 67% (10/15) in the placebo group, treatment with amoxicillin did not significantly impact colonization at the time of delivery (P=0.20).
CONCLUSION: A regimen of outpatient amoxicillin was associated with persistent GBS colonization in 43% of women at the time of labor. Oral prenatal antibiotic prophylaxis against GBS does not sufficiently reduce colonization to preclude intrapartum intravenous antibiotics.