Abstract Title:

Prenatal bisphenol A exposure alters epithelial cell composition in the rhesus macaque fetal oviduct.

Abstract Source:

Toxicol Sci. 2018 Oct 8. Epub 2018 Oct 8. PMID: 30295897

Abstract Author(s):

Pei-Hsuan Hung, Laura S Van Winkle, Carmen J Williams, Patricia A Hunt, Catherine A VandeVoort

Article Affiliation:

Pei-Hsuan Hung


Bisphenol A (BPA) is an endocrine disrupting compound that is a pervasive environmental contaminant. Although it has been reported to affect the development of a variety of fetal reproductive tissues, data on the effect of fetal BPA exposure on oviducts were extremely limited and were only available in mice. To determine if there are adverse effects of gestational BPA exposure on fetal oviduct, we exposed pregnant rhesus macaques with female fetuses to oral or non-oral BPA during the last trimester of gestation (day 100 to term). After the treatment, fetal oviducts were collected for morphology evaluation. BPA exposure altered the percentages of different cell types (ciliated, non-ciliated, and secretory) in the fetal oviduct and resulted in a significant high ciliated cell population in the BPA-exposed fetal oviduct. The distribution of ciliated cells on the epithelium in the BPA-exposed fetal oviduct was also altered. Gestational BPA exposure reduced the expression of mucosubstance and uteroglobin in secretory cells in the fetal oviduct. A comparison of the outcome of the fetal oviduct studies with similar outcomes previously reported in the lung from the same fetuses demonstrates that BPA exhibits opposite effects in these two organs. In conclusion, the BPA-associated alterations in the fetal oviduct could potentially affect the oviduct morphology and function later in life with a negative impact fertility. The mechanisms of action of the differential response of the oviduct and lung to BPA exposure require further investigation.

Study Type : Animal Study

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