Prenatal exposure to bisphenol A and risk of allergic diseases in early life.
Pediatr Res. 2017 Jan 31. Epub 2017 Jan 31. PMID: 28141789
BACKGROUND: Prenatal exposure to bisphenol A (BPA) affects immune system and promotes allergy and asthma in mice, but findings in human studies are limited. We investigated whether prenatal exposure to BPA is associated with increased risk of allergic diseases in infants.
METHODS: We measured BPA concentrations in maternal urine samples collected at delivery from 412 women in Wuhan, China. The occurrence of allergic diseases including eczema and wheeze were assessed at age 6 months through questionnaires. We used logistic regression to evaluate the association between urinary BPA levels and the risk of allergic diseases.
RESULTS: Mothers of infants with allergic diseases had significantly higher urinary BPA levels than those of infants without allergic diseases (median: 2.35 vs. 4.55µg/l, P = 0.03). Increased risk of infant allergic diseases was associated with creatinine-adjusted maternal urinary BPA concentrations. And this association was limited to females (OR = 1.36; 95% CI: 1.10-1.79) rather than males. After stratification by maternal age, the association was only significant in infants of mothers who were younger than 25 years old (OR = 1.90; 95% CI: 1.09-3.29).
CONCLUSION: Prenatal exposure to BPA may potentially increase the risk of allergic diseases at very early life in female infants.Pediatric Research (2017); doi:10.1038/pr.2017.20.