Prenatal PMexposure and neurodevelopment at 2 years of age in a birth cohort from Mexico city.
Int J Hyg Environ Health. 2021 Feb 11 ;233:113695. Epub 2021 Feb 11. PMID: 33582606
BACKGROUND: Recent studies have reported that air pollution exposure may have neurotoxic properties.
OBJECTIVE: To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM) exposure and neurodevelopment during the first two years of children's life.
METHODS: Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PMconcentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM.
RESULTS: Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/mof PMwas associated with a decreased language function of -0.38 points (95% CI: -0.77, -0.01). PMexposure at third trimester of pregnancy contributed most to the observed association.
CONCLUSION: Our findings suggest that language development up to 24 months of age may be particularly sensitive to PMexposure during pregnancy.