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Abstract Title:

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis.

Abstract Source:

J Cell Biochem. 2019 Nov 6. Epub 2019 Nov 6. PMID: 31691375

Abstract Author(s):

Renata da Silva Pereira Saccol, Karine Lanes da Silveira, Alessandra Guedes Manzoni, Fátima Husein Abdalla, Juliana Sorraila de Oliveira, Guilherme Lopes Dornelles, Fernanda Barbisan, Daniela Ferreira Passos, Emerson André Casali, Cinthia Melazzo de Andrade, Ivana Beatrice Mânica da Cruz, Daniela Bitencourt Rosa Leal

Article Affiliation:

Renata da Silva Pereira Saccol

Abstract:

Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant-induced arthritis. Animals were divided into control/saline, control/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg) arthritis/saline, and arthritis/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels ofaspartate aminotransferase, thiobarbituric acid-reactive substances, and reactive oxygen species; however, only treatment with 25 or 50 mg/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.

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