Comparative effect of manuka honey on anaerobic parasitic protozoans with standard drug therapy underconditions: A preliminary study.
Indian J Pharmacol. 2018 Jul-Aug;50(4):197-203. PMID: 30505056
BACKGROUND: From the past five decades, metronidazole and tinidazole have been used for treating nonresistant and resistant giardiasis and trichomoniasis. However, due to the occurrence of drug resistance to standard therapy idealizes us to explore some additional therapies which is cost-effective, easy accessibility, and natural which has least side effects. Manuka honey obtained fromis well known for its antibacterial and wound healing properties and is thought to be a better option as an additional therapy.
OBJECTIVE: The present study was conducted to find out the effect of manuka honey on anaerobic protozoans that includesandunderconditions in comparison to metronidazole and tinidazole.
MATERIALS AND METHODS: Axenic culture ofstrain Portland 1 andstrain 413 was used for drug sensitivity assay to tinidazole, metronidazole, and manuka honey with the highest concentration of 17.1μg/ml, 24.7 μg/ml, and 50%v/v by using (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole). For this, head-to-head comparison has been done and ICof the standard drug as well as manuka honey was calculated.
RESULTS: The result showed that percentage inhibition on the growth of both the parasites is dependent on concentration as well as exposure time of the drug. The calculated ICwas found to be 5.6%v/v and 1.5%v/v for manuka honey with respect toand.
CONCLUSION: The present study suggests that manuka honey can be used as an additional therapy for the patient with giardiasis or trichomoniasis. However,study in the near future will elucidate more about the effectiveness of honey in treating parasitic infections.