Apigenin and Breast Cancers: from Chemistry to Medicine.
Anticancer Agents Med Chem. 2015 Mar 4. Epub 2015 Mar 4. PMID: 25738871
Seyed Mohammad Nabavi
Breast cancer is one of the most common causes of the death among women worldwide. Metabolic disorders, alcohol consumption, hormone replacement therapy, genetic susceptibility, not having children are well known breast cancer risk factors. Surgical resection, radiation therapy, and chemotherapy are limited treatment options for breast cancer. Thus, there is growing need to find new chemopreventive agents that may be effective in prevention or management of breast cancer. Natural products such as flavonoids provide a variety of anticancer compounds which can be useful for prevention or treatment of breast cancer. The usefulness of dietary phytochemicals in prevention of breast cancers is supported by a plethora of experimental and epidemiological studies. Apigenin, a well-known flavone, is found in several dietary plant foods, such as parsley, celery, thyme, celeriac, chamomile, onions, lemon balm, and oranges. Extensive studies have shown that apigenin have potent antioxidant, anti-inflammatory, and anticarcinogenic properties. The aim of the present work is to review the available data obtained from in vitro and in vivo studies on the promising role of apigenin against breast cancer. We also review molecular mechanisms underlying the anticancer effects, natural sources, bioavailability, as well as the chemistry of apigenin.