Preventive effect of Quercetin in a triple transgenic Alzheimer's disease mice model. - GreenMedInfo Summary
Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model.
Molecules. 2019 Jun 20 ;24(12). Epub 2019 Jun 20. PMID: 31226738
Alzheimer's disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable nutritional factors such as diet. Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties. In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer's disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects onβ-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might helpto delay the development of histopathological hallmarks and cognitive function deficits in AD.