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Abstract Title:

Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation.

Abstract Source:

Anticancer Drugs. 2019 Oct 22. Epub 2019 Oct 22. PMID: 31651438

Abstract Author(s):

Shuangfei Guo, Wei Zhu, Ziqing Yin, Ding Xiao, Qiang Zhang, Tang Liu, Jiangdong Ni, Zhengxiao Ouyang, Hongming Xie

Article Affiliation:

Shuangfei Guo

Abstract:

We have previously demonstrated the pivotal role of Jnk-mediated Irf-3/c-Jun in regulating nuclear factor kappa-Β ligand (RANKL)-induced osteoclastogenesis. Here, we demonstrated that proanthocyanidins (PACs) target Irf-3 to alleviate breast cancer-induced activation of osteoclasts. We also found that PACs induced apoptosis of osteoclast precursors by upregulating the ratio of bax/bcl-2 and activating caspase-3 activity. Such bone protective effect also could be observed in a bone metastasis model of breast cancer. These findings provided a novel therapeutic intervention targeting abnormal bone metabolism to alleviate bone metastasis of breast cancer.

Study Type : In Vitro Study

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Sayer Ji
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