Article Publish Status: FREE
Abstract Title:

Effect of the probioticIS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis.

Abstract Source:

Iran J Microbiol. 2019 Apr ;11(2):145-150. PMID: 31341569

Abstract Author(s):

Reza Ranuh, Alpha Fardah Athiyyah, Andy Darma, Vitria Prasetyo Risky, Wibi Riawan, Ingrid S Surono, Subijanto Marto Sudarmo

Article Affiliation:

Reza Ranuh


Background and Objectives: Microbial communities residing in the gut play a major role in the communication between the gut and the brain through neural, immune, and hormonal routes. Changes in abundance of beneficial intestinal bacteria can affect health of individuals. Conversely, drugs, disease, diet and other factors can alter the gut microbiome. However, there is limited information on the effect of exogenous factors on gut microbiota. In this study, we investigated whether a beneficial bacterium, the probioticIS-10506, can stimulate the gut-brain axis using Wistar rats.

Materials and Methods: The animals were divided into two groups: one receivedIS strain 10506 supplementation, while the control group received no treatment. Activation of the gut-brain axis was evaluated by immunohistochemical analysis of intestinal and brain serotonin (5-HT) and brain neurotrophin (NT), serotonin transporter (5-HTT), and brain-derived neurotrophic factor (BDNF) levels.

Results: The results showed that BDNF (<0.000), NT (<0.000007), and 5-HTT (<0.000007) expression was upregulated in the brain along with intestinal 5-HT (<0.000) level in rats treated withstrain IS-10506 relative to the control group.

Conclusion: The probioticIS-10506 stimulates the gut-brain axis and can potentially promote brain development and function.

Study Type : Animal Study

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