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Abstract Title:

Effect of alive probiotic on insulin resistance in type 2 diabetes patients: Randomized clinical trial.

Abstract Source:

Diabetes Metab Syndr. 2018 Sep ;12(5):617-624. Epub 2018 Apr 10. PMID: 29661605

Abstract Author(s):

Nazarii Kobyliak, Tetyana Falalyeyeva, Galyna Mykhalchyshyn, Dmytro Kyriienko, Iuliia Komissarenko

Article Affiliation:

Nazarii Kobyliak

Abstract:

BACKGROUND: Probiotics have beneficial effect on obesity related disorders in animal models. Despite a large number of animal data, randomized placebo-controlled trials (RCT) concluded that probiotics have a moderate effect on glycemic control-related parameters. However, effect of probiotics on insulin resistance are inconsistent.

AIM: In a double-blind single center RCT, effect of alive multistrain probiotic vs. placebo on insulin resistance in type 2 diabetes patient were assessed.

METHODS: A total of 53 patients met the criteria for inclusion. They were randomly assigned to receive multiprobiotic"Symbiter"(concentrated biomass of 14 probiotic bacteria genera Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium) or placebo for 8-weeks administered as a sachet formulation. The primary main outcome was the change HOMA-IR (homeostasis model assessment-estimated insulin resistance) which calculated using Matthews et al.'s equation. Secondary outcomes were the changes in glycemic control-related parameters, anthropomorphic variables and cytokines.

RESULTS: Supplementation with alive multiprobiotic for 8 weeks was associated with significant reduction of HOMA-IR from 6.85 ± 0.76 to 5.13 ± 0.49 (p = 0.047), but remained static in the placebo group. With respect to our secondary outcomes, HbA1c insignificant decreased by 0.09% (p = 0.383) and 0.24% (p = 0.068) respectively in placebo and probiotics groups. However, in probiotic responders (n = 22, patient with decrease in HOMA-IR) after supplementation a significant reduction in HbA1c by 0.39% (p = 0.022) as compared to non-responders was observed. In addition, from markers of chronic systemic inflammatory state only TNF-α and IL-1β changes significantly after treatment with probiotics.

CONCLUSION: Probiotic therapies modestly improved insulin resistance in patients with type 2 diabetes.

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