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Abstract Title:

ProbioticGG Induces Alterations in Ileal Microbiota With Associated CD3CD19T-betIFNγCell Subset Homeostasis in Pigs Challenged WithSerovar 4,[5],12:i:.

Abstract Source:

Front Microbiol. 2019 ;10:977. Epub 2019 May 7. PMID: 31134022

Abstract Author(s):

Wei Zhang, Qiong Wu, Yaohong Zhu, Guiyan Yang, Jiao Yu, Jiufeng Wang, Haifeng Ji

Article Affiliation:

Wei Zhang

Abstract:

serovar 4,[5],12:i:- (4,[5],12:i:-) is an emerging foodborne pathogen causing salmonellosis in humans and animals. ProbioticGG (LGG) is an effective strategy for controlling enteric infections through maintaining gut microbiota homeostasis and regulating the intestinal innate immune response. Here, LGG was orally administrated to newly weaned piglets for 1 week before4,[5],12:i:- challenge.4,[5],12:i:- challenge led to disturbed gut microbiota, characterized by increased levels of, and unculturedpopulations, as well as an aberrant correlation network in-centric species. The beneficial effect of LGG correlated with attenuating the expansion of.only found in the pigs treated with LGG was positively correlated withand. Administration of LGG induced the expansion of CD3CD19T-betIFNγand CD3CD19T-betIFNγcell subsets in the peripheral blood at 24 h after a challenge of4,[5],12:i:-.4,[5],12:i:- infection increased the population of intraepithelial CD3CD19T-betIFNγand CD3CD19T-betIFNγcells in the ileum; however, this increase was attenuated via LGG administration. Correlation analysis revealed that LGG enrichedandpopulations, which were negatively correlated with intraepithelial CD3CD19T-betIFNγand CD3CD19T-betIFNγcells in the ileum. The present data suggest that probiotic LGG alters gut microbiota with associated CD3CD19T-betIFNγcell subset homeostasis in pigs challenged with4,[5],12:i:-. LGG may be used in potential gut microbiota-targeted therapy regimens to regulate the specific immune cell function and, consequently, control enteric infections.

Study Type : Animal Study

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