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Article Publish Status: FREE
Abstract Title:

Probiotics May Have Beneficial Effects in Parkinson's Disease:Evidence.

Abstract Source:

Front Immunol. 2019 ;10:969. Epub 2019 May 7. PMID: 31134068

Abstract Author(s):

Luca Magistrelli, Angela Amoruso, Luca Mogna, Teresa Graziano, Roberto Cantello, Marco Pane, Cristoforo Comi

Article Affiliation:

Luca Magistrelli

Abstract:

Parkinson's disease (PD) is characterized by loss of dopaminergic neurons and intraneuronal accumulation of alpha-synuclein, both in the basal ganglia and in peripheral sites, such as the gut. Peripheral immune activation and reactive oxygen species (ROS) production are important pathogenetic features of PD. In this context, the present study focused on the assessment ofeffects of probiotic bacterial strains in PBMCs isolated from PD patients vs. healthy controls.40 PD patients and 40 matched controls have been enrolled. Peripheral blood mononuclear cells (PBMCs) were isolated and co-cultured with a selection of probiotics microorganisms belonging to theandgenus.release of the major pro- (Tumor Necrosis Factor-alpha and Interleukin-17A and 6) and anti-inflammatory (Interleukin 4 and 10) cytokines by PBMCs, as well as the production of ROS was investigated. Furthermore, we assessed the ability of probiotics to influence membrane integrity, antagonize the growth of potential pathogen bacteria, such asandand encode tyrosine decarboxylase genes ().All probiotic strains were able to inhibit inflammatory cytokines and ROS production in both patients and controls. The most striking results were obtained in PD subjects withLS01 andwhich significantly reduced pro-inflammatory and increased the anti-inflammatory cytokines (<0.05). Furthermore, most strains determined restoration of membrane integrity and inhibition ofand. Finally, we also showed that all the strains do not carrygene, which is known to decrease levodopa bioavailability in PD patients under treatment.Probiotics exert promisingresults in decreasing pro-inflammatory cytokines, oxidative stress and potentially pathogenic bacterial overgrowth.longitudinal data are mandatory to support the use of bacteriotherapy in PD.

Study Type : In Vitro Study

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