Prophylactic Effects ofon Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis.
Front Behav Neurosci. 2019 ;13:126. Epub 2019 Jun 18. PMID: 31275120
Stress disturbs the balance of the gut microbiota and stimulates inflammation-to-brain mechanisms. Moreover, stress leads to anxiety and depressive disorders.displays distinct anti-inflammatory effects. However, no report has focused on the anxiolytic and antidepressant effects ofrelated to the gut microbiome and the inflammation on chronic restraint stress (CRS) in mice. We found that pretreatment withincreased the time spent in the center of the open field apparatus, increased the percentage of entries into the open arms of the elevated plus-maze (EPM) and the percentage of time spent in the open arms of the EPM, and decreased the immobility duration in the tail suspension test as well as the forced swimming test (FST). Moreover,increased the sequence proportion ofand reduced the sequence proportion ofin feces. Furthermore,markedly reduced the protein expression of interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), p-nuclear factor-kappa B (NF-κB) p65 and Iba1 and elevated brain derived neurotrophic factor (BDNF) expression in the hippocampus. We conclude that the anxiolytic and antidepressant effects ofare related to reducing inflammatory cytokines and rebalancing the gut microbiota.