Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.
Int J Mol Sci. 2012 ;13(9):11773-82. Epub 2012 Sep 18. PMID: 23109882
The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body (60)Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p<0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p<0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.