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Article Publish Status: FREE
Abstract Title:

Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides.

Abstract Source:

Molecules. 2017 Jan 7 ;22(1). Epub 2017 Jan 7. PMID: 28067864

Abstract Author(s):

Fatima-Ezzahra Saih, Pierre Andreoletti, Stéphane Mandard, Norbert Latruffe, M'Hammed Saïd El Kebbaj, Gérard Lizard, Boubker Nasser, Mustapha Cherkaoui-Malki

Article Affiliation:

Fatima-Ezzahra Saih

Abstract:

In this study, we aimed to evaluate the antioxidant and anti-inflammatory properties ofcactus cladode extracts in microglia BV-2 cells. Inflammation associated with microglia activation in neuronal injury can be achieved by LPS exposure. Using four different structurally and biologically well-characterized LPS serotypes, we revealed a structure-related differential effect of LPS on fatty acidβ-oxidation and antioxidant enzymes in peroxisomes:-LPS decreased ACOX1 activity while-LPS reduced only catalase activity. Different cactus cladode extracts showed an antioxidant effect through microglial catalase activity activation and an anti-inflammatory effect by reducing nitric oxide (NO) LPS-dependent production. These results suggest that cactus extracts may possess a neuroprotective activity through the induction of peroxisomal antioxidant activity and the inhibition of NO production by activated microglial cells.

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