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Article Publish Status: FREE
Abstract Title:

Protective Effect of Hyperforin onβ Amyloid Protein Induced Apoptosis in PC12 Cells and Colchicine Induced Alzheimer's Disease: An Anti-oxidant and Anti-inflammatory Therapy.

Abstract Source:

J Oleo Sci. 2018 ;67(11):1443-1453. PMID: 30404965

Abstract Author(s):

Xu Jiang, Mukesh Kumar, Yonglin Zhu

Article Affiliation:

Xu Jiang

Abstract:

The current investigation aimed to scrutinize the neuro-protective effect of hyperforin onβ‑amyloid peptide (Aβ)and HOinduced injury in PC12 cells and colchicine induced Alzheimer's disease (AD). PC12 cells were treated with HOand (Aβ)in the presence of hyperforin. The cell viability was determined via suing the MTT assay; malondialdehyde (MDA) and lactate dehydrogenase (LDH) levels were also scrutinized. Colchicine induced the destruction of memory and learning which was exhibited in neurobehavioral theory (passive avoidance and Morris water maze) connected with reduced activity of acetylcholinesterase (AChE). Anti‑oxidant and inflammatory parameters also estimated. Hyperforin dose dependently increased the cell viability and reduced the MDA and LDH release via PC12 cell injured with HOand (Aβ). Hyperforin treatment lead to a considerable enhance in TLT in the retention trials as comparisian to acquisition trial suggesting as boosting memory and learning in rats. Hyperforin treatments significantly increase the AChE and reduced the superoxide dismutase, glutathione, MDA, protein carbonyl, glutathione peroxdiase, catalase, NF‑kB and IL‑1β at dose dependent manner. In summary, the model of HOand (Aβ)induced PC12 cell injury was successfully developed and dose dependently treatment of hypoforin showed the neuroprotective effect against the HOand (Aβ)induced cell damage. These finding clearly exhibited that hyperforin reverted the colchicine induced neuro‑chemical and behavioural alteration via potent anti‑inflammatory and anti‑oxidant activity.

Study Type : In Vitro Study

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Sayer Ji
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