n/a
Abstract Title:

Protective effect of melatonin against herbicides-induced hepatotoxicity in rats.

Abstract Source:

Toxicol Res (Camb). 2021 Jan ;10(1):1-10. Epub 2021 Jan 5. PMID: 33613967

Abstract Author(s):

Lécio Leone Almeida, Giovanna Silva Girão Nobre Pitombeira, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira, Valdemiro Amaro Silva Júnior, Leucio Duarte Vieira Filho, Joaquim Evêncio Neto

Article Affiliation:

Lécio Leone Almeida

Abstract:

Exposure to the herbicides Paraquat and Roundup® may cause cell lesions due to an increase in oxidative stress levels in different biological systems, even in the liver. The aim of this study was to analyze the effect of melatonin on liver of rats exposed to herbicides. A total of 35 rats were randomly divided into seven equal-sized groups: control, Paraquat, Roundup®, Paraquat + Roundup®, Paraquat + melatonin, Roundup® + melatonin, and Paraquat + Roundup® + melatonin. Samples of blood and hepatic tissue were collected at the end of the seventh day of exposure and treatment with melatonin. Body weight, hematological parameters, and histopathological, biochemical analyses and determination of oxidative stress levels in liver were evaluated. Body weight was compromised ( < 0.01). Alterations of hematologic parameters were significant when compared to control ( < 0.001). Biochemically, serum levels of albumin decreased ( < 0.001), but serum levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase increased ( < 0.001). Histopathology revealed necrotic hepatocytes, portal and central-lobular inflammatory infiltrate, congestion of capillaries. Serum levels of thiobarbituric acid reactive substances were found to be significantly elevated ( < 0.05; < 0.001), and serum level of reduced glutathione was significantly lower ( < 0.05; < 0.001). The groups treated concomitantly with melatonin revealed results similar to those of the control. However, melatonin acted as a protective agent for the liver against experimentally induced hepatic toxicity, promoting prevention of body weight, oxidative stress, and normalization of hematological and biochemical parameters.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.