Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats. - GreenMedInfo Summary
Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats.
Andrologia. 2020 Feb 5:e13524. Epub 2020 Feb 5. PMID: 32022330
Fatih Mehmet Kandemir
This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin-100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl) group received 1.23 mg/kg/b.w. of HgClfor 7 days. Mercury chloride + rutin-50 group received 50 mg/kg/b.w. rutin and HgCl1.23 mg/kg/b.w. for 7 days. HgCl + rutin-100 group received 100 mg/kg/b.w. rutin and HgCl1.23 mg/kg/b.w. for 7 days. It was detected that HgCltreatment increased malondialdehyde (MDA) levels, tumour necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused byHgCl. In conclusion, rutin administration may treat HgCltoxicity in testes.