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Abstract Title:

Protective effects of cycloartane triterpenoides from Passiflora edulis Sims against glutamate-induced neurotoxicity in PC12 cell.

Abstract Source:

Fitoterapia. 2016 Dec ;115:122-127. Epub 2016 Sep 28. PMID: 27693740

Abstract Author(s):

Feng-Qing Xu, Ning Wang, Wei-Wei Fan, Cheng-Ting Zi, Hong-Su Zhao, Jiang-Miao Hu, Jun Zhou

Article Affiliation:

Feng-Qing Xu

Abstract:

Four new cycloartane triterpenoids, 1α,3β-dihydroxy-16-keto-24(31)-en-cycloartane (1), 31-methoxyl-passifloic acid (2), cyclopassifloside XIV (3), and cyclopassifloside XV (4), together with six known compounds (5-10) were isolated from Passiflora edulis Sims. Their structures were elucidated on the basis of extensive spectroscopic analysis. All the compounds were evaluated for protective effects against damage of PC12 cell induced by glutamate according to traditional usage of the herbal medicine, and the results indicated that cycloartane triterpenoids maybe one of the active compositions of P. edulis Sims for the treatment of neurodegenerative disease.

Study Type : In Vitro Study

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Sayer Ji
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