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Article Publish Status: FREE
Abstract Title:

Protective Effects of Ellagitannin-Rich Strawberry Extracts on Biochemical and Metabolic Disturbances in Rats Fed a Diet High in Fructose.

Abstract Source:

Nutrients. 2018 Apr 4 ;10(4). Epub 2018 Apr 4. PMID: 29617310

Abstract Author(s):

Bartosz Fotschki, Jerzy Juśkiewicz, Krzysztof Kołodziejczyk, Adam Jurgoński, Monika Kosmala, Joanna Milala, Katarzyna Ognik, Zenon Zduńczyk

Article Affiliation:

Bartosz Fotschki

Abstract:

The present study compares the effects of two dietary strawberry extracts rich in monomeric (ME) or dimeric (DE) ellagitannins (ETs) on gastrointestinal, blood and tissue biomarkers in Wistar rats fed high-fructose diets. Both strawberry extracts beneficially affect the antioxidant status and lipid profile of the liver and serum. The ME extract shows a greater ability to inhibit lipid peroxidation in kidneys, more effectively decreases serum and liver triglycerides, and exerts greater anti-inflammatory effects in blood serum than the DE extract. The DE extract significantly reduces the activity of microbial enzymes in the cecum. These effects might be associated with higher cecum and urine levels of ET metabolites in rats fed with ME than in rats fed with DE. In conclusion, the diet-induced fructose-related disturbances observed in biochemical parameters are regulated by both extracts; nevertheless, the beneficial effects of the ME extract are mostly associated with systemic parameters, while those of the DE extracts are associated with local microbial activity.

Study Type : Animal Study

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Sayer Ji
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