Abstract Title:

Protective effects of hydroalcoholic extracts from an ancient apple variety 'Mela Rosa dei Monti Sibillini' against renal ischemia/reperfusion injury in rats.

Abstract Source:

Food Funct. 2019 Nov 1 ;10(11):7544-7552. Epub 2019 Nov 5. PMID: 31686074

Abstract Author(s):

Hasan Yousefi-Manesh, Sara Hemmati, Samira Shirooie, Seyed Mohammad Nabavi, Azita Talebzadeh Bonakdar, Reza Fayaznia, Mohammad Hossein Asgardoon, Ali Zare Dehnavi, Mohammad Ghafouri, Joice G Nkuimi Wandjou, Giovanni Caprioli, Stefania Sut, Filippo Maggi, Stefano Dall'Acqua

Article Affiliation:

Hasan Yousefi-Manesh


The purpose of this work was to investigate the effect of hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple variety of central Italy, the 'Mela Rosa dei Monti Sibillini', on the damage caused by renal ischemia/reperfusion injury (IRI) in rats. Thirty mg per kg b.w. of the extracts were administered intraperitoneally to male adult Wistar rats 3 days before the induction of IRI by pedicle clamping. A significant decrease in the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNFα), interleukin 1 beta (IL-1β) and nuclear factor-κB (NF-κB) was observed in the groups pre-treated with APE when compared with IRI rats. The chemical composition of APE was determined by HPLC-DAD-MShighlighting a significant amount of proanthocyanidins (52.9 mg g), flavonols (42.27 mg g) and dihydrochalcones (11.75 mg g). These findings indicated that this ancient apple variety is a promising source of nutraceuticals and functional foods helpful to manage complications of renal disorders.

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