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Abstract Title:

Protective effects of kolaviron and gallic acid against cobalt-chloride-induced cardiorenal dysfunction via suppression of oxidative stress and activation of the ERK signaling pathway.

Abstract Source:

Can J Physiol Pharmacol. 2016 Dec ;94(12):1276-1284. Epub 2016 Jul 5. PMID: 27548501

Abstract Author(s):

Akinleye Stephen Akinrinde, Olutayo Omobowale, Ademola Oyagbemi, Ebunoluwa Asenuga, Temitayo Ajibade

Article Affiliation:

Akinleye Stephen Akinrinde

Abstract:

Cobalt (Co) toxicity is a potential public health problem due to recent renewed use of Co in orthopedic implants, dietary supplements, and blood doping in athletes and horses. We investigated the protective roles of kolaviron (KV), a bi-flavonoid of Garcinia kola, and gallic acid (GA) on cobalt chloride (CoCl)-induced cardiorenal damage in rats. CoClcaused significant increases (p<0.05) in serum creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), xanthine oxidase (XO), urea, creatinine, malondialdehyde, HO, nitric oxide, as well as C-reactive protein expression, along with significant (p<0.05) reduction in cardiac and renal expression of extracellular signal regulated kinase (ERK) and the activities of superoxide dismutase, catalase, and glutathione S-transferase. KV and GA prevented the toxic effects of CoClby stimulating ERK expression and reversing Co-induced biochemical changes. Administration of CoClalone did not significantly alter ECG patterns in the rats, although co-treatment with KV (200 mg/kg) produced QT-segment prolongation and also appeared to potentiate Co hypotension. Histopathology of the heart and kidneys of rats treated with KV and GA confirmed the biochemical data. KV and GA thus protected against cardiac and renal damage in Co intoxication via antioxidant and (or) cell survival mechanisms, possibly involving ERK activation.

Study Type : Animal Study

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