Protective effects of liquiritin on the brain of rats with Alzheimer's disease. - GreenMedInfo Summary

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Abstract Title:

Protective Effects of Liquiritin on the Brain of Rats with Alzheimer's Disease.

Abstract Source:

West Indian Med J. 2015 12 ;64(5):468-472. Epub 2016 Apr 29. PMID: 27399208

Abstract Author(s):

X Huang, Y Wang, K Ren

Article Affiliation:

X Huang

Abstract:

Background: Alzheimer's disease (AD) is a sort of nerve degenerative disease with clinical manifestation of memory damage and cognitive dysfunction. Its typical pathological change is the abnormal deposition of amyloid-beta (Aβ).

Method: In this study, a rat AD model with liquiritin (LQ) interference was established to observe the effects of LQ on the AD rats' behavioural memory and primary hippocampus cells.

Results: Liquiritin had the effect of improving the rats' learning and memory ability, enhancing the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in rats' brain tissues, increasing the antioxidant ability, protecting the primary cultured hippocampal neurons and inhibiting the apoptosis induced by Aβ.

Conclusion: The protective effects of LQ can be related to the enhancement of antioxidase activity and clearance of oxygen radicals.

Article Published Date : Jan 11, 2015
Study Type : Animal Study
Additional Links
Substances : Licorice : CK(1045) : AC(465)
Diseases : Alzheimer's Disease : CK(3372) : AC(2000)
Pharmacological Actions : Antioxidants : CK(21528) : AC(13231), Catalase Up-Regulation : CK(368) : AC(149), Neuroprotective Agents : CK(10404) : AC(6995), Superoxide Dismutase Up-regulation : CK(2090) : AC(812)

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Key Research Topics

Substance

Licorice

Disease

Alzheimer's Disease

Pharmacological Actions

Antioxidants
Neuroprotective Agents
Superoxide Dismutase Up-regulation
Catalase Up-Regulation

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