n/a
Abstract Title:

Protective effects of resveratrol on hyperoxia-induced lung injury in neonatal rats by alleviating apoptosis and ROS production.

Abstract Source:

J Matern Fetal Neonatal Med. 2019 Mar 19:1-141. Epub 2019 Mar 19. PMID: 30890012

Abstract Author(s):

Xiaodan Zhu, Xiaoping Lei, Junyi Wang, Wenbin Dong

Article Affiliation:

Xiaodan Zhu

Abstract:

BACKGROUND: Bronchopulmonary dysplasia (BPD) is one of the most common long-term lung complications of prematurely born infants caused by prolonged injury and repair during immature lung development. Resveratrol has reported to exert anti-inflammatory, antioxidation and antiapoptosis effects. However, it was not clear whether resveratrol played a protective role in rat model of BPD through antiapoptosis effect. This study aimed to investigate the effect of resveratrol in BPD.

METHODS: Neonate rats were delivered spontaneously and randomized divided into four groups on postnatal day (PN) 0.5: room air (21% O) + dimethyl sulfoxide (DMSO), room air + resveratrol, hyperoxia (80%) + DMSO, hyperoxia + resveratrol. Lung tissues were collected on PN1, PN7 and PN14. Protective effects of resveratrol on hyperoxia-induced lung injury were evaluated by hematoxylin and eosin (HE) staining, TUNEL staining, reactive oxygen species (ROS) detection, qRT-PCR and western blotting.

RESULTS: Hyperoxia-induced alveolar simplification and apoptosis were alleviated by resveratrol; resveratrol reduced ROS production, up-regulated SIRT1, decreased the expressing of p53 and acetyl-p53 in the lung of hyperoxia-exposed neonatal rats.

CONCLUSIONS: This study showed that resveratrol alleviated hyperoxia-induced apoptosis in neonatal rats lung tissue via reducing ROS and p53. Resveratrol induced SIRT1 upregulation and acetyl-p53 reduction may also be involved in lung protection.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.