The prowess of andrographolide as a natural weapon in the war against cancer. - GreenMedInfo Summary
The Prowess of Andrographolide as a Natural Weapon in the War against Cancer.
Cancers (Basel). 2020 08 4 ;12(8). Epub 2020 Aug 4. PMID: 32759728
Ammad Ahmad Farooqi
There has been a paradigm shift in our understanding about the multifaceted nature of cancer, and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographolide, a diterpene lactone fromwas brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. Here we reviewed andrographolide on cellular pathways regulation including Wnt/β-catenin, mTOR, VEGF-mediated intracellular signaling, as well as TRAIL-mediated apoptosis to inhibit cancer development.